My passion for cancer research stems from the early work starting in the 1940’s by Gross, Prehn and Main, and the Klein’s work that clearly demonstrated that an immunization with tumor cells provides complete concomitant immunity against a subsequent tumor challenge. The recent scientific advancements in genomics and immunology have begun to identify the factors that contribute to this complete immunity. Yet, not a single therapy has proven strong enough to show the same highly specific protection to a subsequent tumor challenge as whole tumor cell immunization. This gap in our knowledge is where my research interests reside.